用海洋藻衍生的生物活性化学物质改善癌症治疗:一篇综述
B Parveen1, Mathiyazhagan Narayanan2
1Department of Biotechnology, Research and Innovation, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, SIMATS, Thandalam, Chennai-602 105, Tamil Nadu, India.
Naunyn-Schmiedeberg's archives of pharmacology
|July 9, 2025
概括
海洋生物活性化合物在癌症治疗中表现有前途,特别是在增强有效性和减少副作用的组合中. 需要进一步的研究来探索各种海洋来源和新型抗癌疗法的协同作用机制.
科学领域:
- 海洋生物学 海洋生物学
- 药理学 药理学是指药理学的学科.
- 在瘤学瘤学.
背景情况:
- 来自海洋的生物活性化学物质为癌症治疗提供了治疗潜力.
- 这些化合物的协同作用组合可以提高疗效并降低毒性.
- 海洋生态系统是各种化合物的丰富来源,具有独特的抗癌特性.
研究的目的:
- 系统地审查过去20年关于海洋生物活性化学品在癌症治疗中的协同作用和添加作用的文献.
- 研究作用机制,潜在的组合和健康益处.
- 确定该领域的局限性和研究缺口.
主要方法:
- 对科学数据库的系统文献审查 (科学网,PubMed,Scopus).
- 分析了708篇文章,其中60篇根据系统审查和元分析 (PRISMA) 标准的首选报告项目进行了选择.
- 专注于海洋衍生抗癌化合物的协同和添加结果.
主要成果:
- 与单个化合物相比,海洋生物活性物质的融合显著提高了生物可用性和治疗效果.
- 协同作用会增强癌细胞的向性,降低毒性,改善患者的治疗结果.
- 文献显示过度强调胡卜素和鱼油,其他海洋衍生组合的探索不足.
结论:
- 海洋生物活性化学物质组合具有开发新型和有效抗癌治疗的巨大潜力.
- 进一步的研究对于探索各种海洋化合物,阐明协同机制和优化配方至关重要.
- 增加研究举措,资金和跨学科合作对于利用海洋生物多样性用于癌症治疗至关重要.
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