高灵敏度C反应蛋白,囊素C和中年和老年参与者患有肉类的全因死亡率之间的关联
Yunteng Fang1,2, XiaoYan Wu2, Jiayi Shen1,2
1Zhejiang University Lishui Hospital, Lishui, China.
Aging clinical and experimental research
|July 9, 2025
概括
高敏感性C反应蛋白 (hs-CRP) 和囊素C (CysC) 水平的升高与老年人患有肉类的全因死亡率的增加有关. 结合这些生物标志物可能会改善这一群体的死亡率预测.
科学领域:
- 老年学是一门学科.
- 生物标志物研究 生物标志物研究
- 临床医学 临床医学
背景情况:
- 高灵敏度C反应蛋白 (hs-CRP) 和囊素C (CysC) 是已确立的炎症和功能预后指标.
- 它们与患有肉类的个体的死亡率的关联仍然是研究领域.
研究的目的:
- 研究hs-CRP和CysC度升高与中年和老年被诊断患有肉类的中年人和老年人的全因死亡率之间的关系.
- 评估hs-CRP和CysC的综合预后值,以预测该队列中的死亡率.
主要方法:
- 对612名患有皮症的中国人进行了回顾性分析.
- hs-CRP和CysC水平分为三级;用于确定危险比率 (HR) 和95%置信区间 (CI) 的考克斯回归模型.
- 根据两种生物标志物的高风险截止值,分组参与者分析了组合效应;进行了子组分析.
主要成果:
- 在随访期间,共有130人死亡,死亡率为21.2%.
- 作为连续变量,hs-CRP和CysC都显示出与全因死亡率有显著的关联;hs-CRP还对死亡率进行了明确的预测.
- 高hs-CRP和CysC的组合表明与死亡率有显著的积极关联 (HR=2.26,95%CI:模型3中的1.01-5.07),特别是在75岁以上的男性中.
结论:
- hs-CRP和CysC显示出对中老年和老年人患有肉症的潜在有用的预后指标.
- 对hs-CRP和CysC的综合评估有效预测了这一群体的死亡风险.
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