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Updated: Sep 16, 2025

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis
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使用Ligand破译人类癌症的MHC免疫组.MHC地图

Zhi Ran1,2,3, Meilin Mu4,5,6, Shaofeng Lin7

  • 1Department of Orthopaedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.

Briefings in bioinformatics
|July 9, 2025
PubMed
概括

我们开发了一种新的管道,从大规模的免疫瘤学数据中识别瘤特异性免疫连接物,创建一个全面的地图,以推进癌症疫苗和免疫疗法.

关键词:
由HLA呈现的配体.基于T细胞的瘤表位.癌症免疫疗法免疫疗法免疫类药物 免疫类药物瘤免疫力 免疫力

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Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
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Complete antigens possess both immunogenicity and...
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Antigen Processing Pathways

MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
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