血液透析对大脑和心脏的影响使用多参数MRI评估
Eleanor F Cox1,2, Venkata Rukmini Latha Gullapudi3,4, Charlotte E Buchanan1
1Sir Peter Mansfield Imaging Centre, School of Physics & Astronomy, University of Nottingham, Nottingham, UK.
概括
血液透析患者在治疗期间脑水含量增加,表明急性变化. 慢性MRI扫描显示,与健康个体相比,这些患者的大脑衰老加速.
科学领域:
- 神经成像是一种神经成像.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心血管成像 - 心血管成像
背景情况:
- 在血液透析 (HD) 患者中,认知障碍很常见,影响生活质量.
- 大脑磁共振成像 (MRI) 可以评估HD患者的急性和慢性变化.
- 加快的大脑衰老是慢性病和HD治疗的潜在后果.
研究的目的:
- 通过使用MRI来研究在HD期间大脑水含量的急性变化.
- 为了比较慢性脑结构和扩散MRI测量在HD患者和健康志愿者 (HV) 之间.
- 为了确定与HD患者相比,HD患者是否表现出加速的大脑衰老.
主要方法:
- 在HD期间进行了3T核磁共振扫描,以测量白质 (WM) T1.的急性变化.
- 慢性MRI评估脑结构 (体积,T1) 和扩散 (FA,MD) 在HD患者前透析和年龄/性别匹配的HVs.
- 还分析了心脏MRI测量结果.
主要成果:
- 白质T1在HD期间急剧增加,表明大脑含水量较高.
- 与HV患者相比,HD患者的灰质 (GM) 和WM体积较低.
- 患有HD的患者表现出较低的分数异构性 (FA) 和较高的平均扩散性 (MD),表明大脑衰老加速.
结论:
- HD急剧增加白物质的水含量,可能是由于透梯度.
- 慢性MRI发现表明HD患者的大脑衰老加速.
- 这些大脑变化可能会导致HD患者的认知障碍和病理变化.
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