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Updated: Sep 16, 2025

Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model
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通过Simcyp模拟器预测药物转移到人乳中:来自 ConcePTION项目的贡献

Julia Macente1, Nina Nauwelaerts1, Justine Marine Badée2

  • 1Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.

CPT: pharmacometrics & systems pharmacology
|July 9, 2025
PubMed
概括

基于生理学的药理动力学 (PBPK) 模型在母乳养安全方面得到了改进. 新的模型准确地预测了牛奶中的药物含量,有助于评估母亲使用药物的婴儿风险.

关键词:
母乳养 哺乳期 母乳养每日婴儿剂量 婴儿剂量药物暴露在人乳中的药物暴露孕产妇使用的药物牛奶与血的比率是什么围产期药理学 围产期药理学基于生理学的药理动力学 (PBPK) 建模和仿真.相对婴儿剂量相对婴儿剂量.

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