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Hui Xu^1,2, Li Yin¹, Weiwei Bian^1,3

¹Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

JAMA network open

|July 9, 2025

概括

间歇性肺病 (ILD) 在各种组织学亚型中显著增加患肺癌的风险. 这一发现强调了在肺癌风险评估中考虑ILD的重要性.

科学领域:

肺部医学肺部医学
在瘤学瘤学.
流行病学流行病学

背景情况:

间歇性肺病 (ILD) 和肺癌之间的假设关联尚未最终确立.
之前的研究在检查这种潜在联系时没有充分控制遗传因素.

研究的目的:

为了研究间歇性肺病 (ILD) 与随后发展不同肺癌组织学亚型的风险之间的联系.
评估这一关联在一般人群和兄弟姐妹控制的队列中,以考虑遗传因素.

主要方法:

一项大规模的前性队列研究,利用瑞典的人口和多代人登记册.
包括1932年至1987年间出生的人,并从1987年至2016年进行随访.
分析使用多变量危险比率 (HRs) 和95%置信区间 (CI),包括兄弟控制的分析.

主要成果:

在对混杂因素进行调整后,ILD患者患肺癌的风险显著增加 (HR,2.16;95% CI,1.89-2.46).
兄弟对照的分析证实了风险增加 (HR,2.91;95% CI,1.98-4.27).
观察到所有主要组织学亚型的风险增加,包括腺癌,状细胞癌和小细胞癌.

结论:

间歇性肺病与大多数肺癌组织学亚型的风险增加有关.
这些发现表明,ILD应纳入肺癌风险评估模型.
这项研究为ILD-肺癌联系提供了强有力的证据,即使在控制了共同的遗传因素之后.

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