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Updated: Sep 8, 2025

Use of Synaptic Zinc Histochemistry to Reveal Different Regions and Laminae in the Developing and Adult Brain
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与ZC4H2相关的罕见疾病的致病因子是突触活动和认知功能的突触后调节器

Li Pear Wan1,2,3, Yuwei Li2, Shuhua Zhao4

  • 1Fujian Key Laboratory of Translational Research in Cancer and Neurodegenerative Diseases, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian 350108, China.

Proceedings of the National Academy of Sciences of the United States of America
|July 9, 2025
PubMed
概括

激发性神经元中的ZC4H2缺乏会通过破坏AMPA受体稳定性而导致认知缺陷. 使用佩拉曼奈尔恢复激发性突触活动,在ZC4H2缺乏的小鼠中改善了认知功能.

关键词:
在AMPA受体上,AMPA受体是ZC4H2 的时间.激发性突触活动激发性突触活动智力障碍 智力障碍是一种智力障碍.对于帕拉曼尼尔来说,这是一个很好的选择.

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