生物学上有意义的效果大小是研究设计的一个因素吗? 一个系统的翻译慢性变量压力研究的系统审查
Crispin Jordan1, Nicola Romanò1,2, John Menzies1,2
1Centre for Discovery Brain Sciences, Edinburgh Medical School: Biomedical Sciences, University of Edinburgh, Edinburgh, UK.
Experimental physiology
|July 9, 2025
概括
大多数动物研究未能使用生物学上有意义的效果大小来计算样本大小,这可能导致研究效率低下. 优先考虑影响大小的确定,提高实验室动物研究的科学严谨性和伦理考虑.
科学领域:
- 实验室动物研究实验室动物研究
- 实验设计 实验设计
- 生物统计学 生物统计学
背景情况:
- 3Rs (取代,减少,改进) 指导伦理动物研究.
- 样本大小的确定对于减少原理至关重要.
- 适当的样本大小可以确保没有过度使用动物的统计能力.
研究的目的:
- 系统地审查体内研究的作者是否使用生物学上有意义的效应大小来确定样本大小.
- 评估在动物研究中报告样本大小的理由.
主要方法:
- 385项动物研究的系统审查.
- 专注于使用慢性变量压力模型的研究.
- 分析报告的样本大小计算和影响大小的考虑.
主要成果:
- 只有一项研究 (在385项研究中) 报告使用生物学上有意义的效应大小来计算样本大小.
- 大多数研究都缺乏对所选择的样本大小的证明.
- 在实验设计中不一致地应用统计原则.
结论:
- 在确定动物研究样本大小时,生物学上有意义的效应大小未被充分利用.
- 促进效果大小的使用对于改善研究设计,统计能力和伦理动物使用至关重要.
- 基于效果大小的样本大小的明确理由提高了研究的可重现性和解释性.
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