通过调节细胞生长方向,JAG调节分泌平度,与AS2相互作用,并受到TCP24的对抗
Xi He1, Shouling Xu2, Avilash Singh Yadav3
1Key Laboratory of Nuclear Agricultural Sciences of Ministry of Agriculture, Institute of Nuclear Agricultural Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.
Cell reports
|July 9, 2025
概括
这种JAGGED (JAG) 基因通过改变细胞生长方向来抑制突变动物的分体表皮曲. JAG与非对称叶子2 (AS2) 进行物理交互,TCP24对抗了JAG,揭示了平面植物器官至关重要的网络.
科学领域:
- 植物生物学 植物生物学
- 发育生物学是发展生物学.
- 分子遗传学 分子遗传学
背景情况:
- 平坦植物的器官对其功能至关重要.
- 极性和组织生长协调保持器官平坦度.
- 外阴非对称叶子2 (AS2) 表达导致突变物体的分体表皮曲.
研究的目的:
- 为了阐明AS2诱导的分体表皮曲背后的分子机制.
- 为了研究JAGGED (JAG) 基因在分泌体形态发生中的作用.
- 为了确定调节植物器官平坦性的遗传相互作用.
主要方法:
- 对as2-7D和jag突变的遗传分析.
- 细胞生长分析.
- 分子相互作用研究 (蛋白与蛋白相互作用,基因表达分析).
主要成果:
- 对JAG的突变抑制了as2-7D突变体中的分体表皮曲表型.
- 突变改变了细胞生长方向,朝着近端-远端轴.
- JAG与AS2进行物理相互作用,而TEOSINTE分支1 (CYCLOIDEA) 和PCFFFAMILY24 (TCP24) 通过抑制JAG转录和AS2-JAG相互作用来对抗JAG活动.
结论:
- JAGGED (JAG) 基因在抑制分体表皮曲方面发挥着至关重要的作用.
- 一个复杂的分子网络涉及AS2,JAG和TCP24,调节分离平度.
- 了解这个网络对于生成平面植物器官至关重要.
相关概念视频
Role of Microtubules in Cell Wall Deposition
2.6K
Microtubules are small hollow tubes in eukaryotic cells. The cell wall microtubules are polymerized dimers of two globular proteins, α-tubulin and β-tubulin, two globular proteins. With a diameter of about 25 nm, microtubules are the widest components of the cytoskeleton. They help the cell resist compression and provide a track along which vesicles move through the cell or pull replicated chromosomes to opposite ends of a dividing cell. Microtubules go through quick cycles of...
2.6K
Morphogenesis
28.8K
Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
28.8K
Cell Signaling in Plants
5.8K
Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...
5.8K
Cell Adhesion in Plants
2.9K
Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...
2.9K
Regulation of Transpiration by Stomata
29.1K
During photosynthesis, plants acquire the necessary carbon dioxide and release the produced oxygen back into the atmosphere. Openings in the epidermis of plant leaves is the site of this exchange of gasses. A single opening is called a stoma—derived from the Greek word for “mouth.” Stomata open and close in response to a variety of environmental cues.
29.1K
Cells Coordinate Growth and Proliferation
4.6K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
4.6K


