在多病症患者中,基于设备的体力活动和低度炎症:来自MOBILIZE试验的横截面基线分析
Alessio Bricca1,2, Grit Elster Legaard3, Sofie Rath Mortensen2,4
1Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
European journal of sport science
|July 9, 2025
概括
身体活动 (PA) 可以减少多种慢性疾病患者的炎症. 即使是最低限度的每日中度至强度的体力活动 (MVPA) 也与较低的炎症标志物有关,支持PA促进多病症.
科学领域:
- 生物医学科学 生物医学科学
- 运动生理学 运动生理学
- 炎症研究的研究.
背景情况:
- 身体活动 (PA) 以其抗炎性质而闻名.
- 在多重疾病 (多种慢性疾病) 患者中,PA对患者的影响尚不清楚.
- 了解PA在这种人群中控制炎症的作用至关重要.
研究的目的:
- 调查设备测量PA和多病症患者的炎症生物标志物之间的关联.
- 为了确定中度至强度体力活动 (MVPA) 水平是否与特定的炎症标志物相关.
- 探索身体质量指数 (BMI) 在这种关系中的潜在调解作用.
主要方法:
- 从MOBILIZE试验中对214名多病症参与者的横截面分析.
- 设备测量的PA (加速计) 和炎症生物标志物 (IL-1ra,hs-CRP,TNF,IL-6) 被评估.
- 调整后的强健回归模型被用于分析关联,BMI作为潜在的调解器.
主要成果:
- 较高的MVPA显著与较低水平的互白素-1受体对抗剂 (IL-1ra) 相关.
- 每增加一分钟的每日MVPA对应于IL-1ra的2%的减少.
- 与那些每天≥10分钟MVPA的参与者相比,与那些每天<1分钟的参与者相比,MVPA水平降低了33% - 45%.
- 体重指数没有调解MVPA和IL-1ra之间的关系.
结论:
- 即使MVPA的微小增加也与多病症患者的低级炎症减少有关.
- 这些发现支持对PA的公共卫生建议,包括对多种慢性疾病患者的建议.
- 促进PA,即使在中度水平,也可能是管理这一群体炎症的可行策略.
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