肌肉的生长是通过肉瘤分裂来实现的
Clement Rodier1, Ian D Estabrook2, Eunice HoYee Chan1
1CNRS, IBDM, Turing Centre for Living Systems, Aix Marseille University, Marseille, France.
Science advances
|July 9, 2025
概括
单个瘤分裂形成新的瘤,使肌肉在发育过程中生长和修复. 这一过程确保肌肉细胞在骨生长时保持机械完整性.
科学领域:
- 肌肉生物学 肌肉生物学
- 发育生物学是发展生物学.
- 细胞力学 细胞力学
背景情况:
- 肉囊是肌肉的基本收缩单位.
- 肌肉细胞通过增加长度而生长,需要新的瘤细胞.
- 在发育过程中添加沙科默的机制以前是未知的.
研究的目的:
- 为了研究肌肉如何添加新的瘤来促进生长.
- 为了了解Drosophila发育过程中 Sarcomere 添加的过程.
主要方法:
- 在发育的Drosophila.中对萨尔科梅尔成分的实时成像.
- 高通量图像分析,以追踪沙尔科默尔的动态.
主要成果:
- 个别的瘤沿着肌纤维张力轴分裂成子瘤.
- 新的瘤被插入肌纤维细胞,保持机械完整性.
- 肉瘤分裂似乎是由紧张和局部损伤引发的.
结论:
- 肉瘤分裂是一种在发育过程中促进肌肉生长的新机制.
- 这个过程修复了受损的瘤,并与骨生长同步肌肉生长.
更多相关视频
08:37Sarcomere Shortening of Pluripotent Stem Cell-Derived Cardiomyocytes using Fluorescent-Tagged Sarcomere Proteins.
Published on: March 3, 2021
4.6K
08:38Engineering Skeletal Muscle Tissues from Murine Myoblast Progenitor Cells and Application of Electrical Stimulation
Published on: March 19, 2013
21.2K
相关概念视频
The Sarcomere
9.5K
A sarcomere is a microscopic segment repeating in a myofibril. The sarcomere fundamentally consists of two main myofilaments: thick filaments called myosin and thin filaments called actin. These filaments interact by sliding past each other in response to stimulus. In addition to myosin and actin, several other proteins, such as tropomyosin, troponin, titin, nebulin, myomesin, α-actinin, and dystrophin, play crucial roles in regulating, structuring, and functioning of the sarcomere.
Each...
Each...
9.5K
Microscopic Anatomy of Skeletal Muscles
15.5K
Skeletal muscle cells, also called muscle fibers, are distinctly elongated, multi-nucleated, slender biological units. They are packed with specialized structures designed to facilitate their primary function, which is contraction.
The muscle sarcolemma is a plasma membrane enclosing each muscle cell that conducts electrical signals called action potentials. The sarcolemma extends into the cell to form T-tubules, ensuring the neural impulses are uniformly distributed across the entire muscle...
The muscle sarcolemma is a plasma membrane enclosing each muscle cell that conducts electrical signals called action potentials. The sarcolemma extends into the cell to form T-tubules, ensuring the neural impulses are uniformly distributed across the entire muscle...
15.5K
Actin and Myosin in Muscle Contraction
14.8K
Actin and myosin are contractile proteins that form the sarcomere found in skeletal muscle tissues for regulating muscle contraction. Actin, a globular contractile protein, interacts with myosin for muscle contraction. The skeletal tissue appears striped or striated under a microscope due to the repeated arrangement of contractile proteins actin and myosin along the length of myofibrils. Dark A bands and light I bands repeat along myofibrils, and the alignment of myofibrils in the cell causes...
14.8K
Formation of Muscle Fibers from Myoblasts
5.2K
De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
5.2K
Cross-bridge Cycle
118.3K
As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
118.3K
Overview of Skeletal Muscle
12.5K
Skeletal muscles are composed of a bundle of muscle fibers and are attached to bones through tendons. Each skeletal muscle fiber is a single muscle cell. The sarcolemma, the plasma membrane of a skeletal muscle cell, consists of a lipid bilayer and glycocalyx that supports muscle fibers. The sarcolemma extends into the muscle cells to form tubular structures called transverse or T-tubules. Each side of the T-tubules consists of a membrane-bound structure called the sarcoplasmic reticulum,...
12.5K
