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Updated: Sep 16, 2025

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
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CYP3A4甲基化对塔克罗利木斯药理动学的影响

Karel K M Koudijs1, Oumaima Etsouli1, Costanza L Vallerga2

  • 1Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, the Netherlands.

Therapeutic drug monitoring
|July 9, 2025
PubMed
概括

在CYP3A4的遗传变异解释了小的塔克罗利斯的变化. 这项研究发现增加的CYP3A4基因甲基化与更高的药物水平相关,解释了18%的药物动力学变化.

关键词:
肝脏 肝脏 肝脏 肝脏 肝脏 肝脏药物动力学 药物动力学这就是塔克罗利斯.治疗药物监测 治疗药物监测移植 移植 移植 移植

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