使用聚焦声波的可行性,以增强通过皮肤传递的可行性
Chih-Hsien Li1, Chuan-Wei Kuo1, Ching-Hsiang Fan2
1Department of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan.
Ultrasonics
|July 9, 2025
概括
聚焦声波 (FAV) 通过创建局部的旋转流来增强通过皮肤传递的药物. 这种安全的超声波方法提高了皮肤的透率,无需化或热,克服了传统方法的局限性.
科学领域:
- 生物医学工程 生物医学工程
- 声学 声学 在声学方面
- 皮肤病学 皮肤病学
背景情况:
- 通过皮肤递送药物提供了一种方便的,非侵入性的施用途径.
- 皮肤的角层 (stratum corneum) 是药物透的重要障碍.
- 现有的超声波方法用于增强通过皮肤传递,由于高能耗和化,引起了安全问题.
研究的目的:
- 引入和评估一种新的1MHz聚焦声 (FAV) 方法,用于通过皮肤递送药物.
- 克服与传统超声波增强的透皮输送方法相关的安全限制.
主要方法:
- 利用相位移来产生带有螺旋波运动的1MHz聚焦声波 (FAV).
- 诱导局部的旋流流与高切削应力.
- 在猪和老鼠皮肤模型中测量了水友染料 (埃文斯蓝色,德克斯) 的流速和评估透增强.
主要成果:
- 在10秒内,FAV立即诱导稳定的旋流 (2.4毫米直径).
- 最佳参数 (1 MPa,60%工作周期) 产生了峰值流速 (1.6 ± 0.4 mm/s).
- 与传统的聚焦超声波相比,使用FAV进行超声波 (3分钟) 显著提高了染料透率 (EB的3.3倍,猪皮中的德克斯的2.1倍).
- 在没有温度升高或惯性空洞化等不良影响的情况下,FAV使EB在老鼠皮肤的透率翻了一番.
结论:
- 通过透角层,FAV方法有效地提高了通过皮肤的药物透率.
- FAV提供了比传统超声波方法更安全的替代方案,避免了洞穴和热风险.
- 这种技术有望提高通过皮肤递送药物系统的疗效.
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