生汁加工对Eucommiae皮质挥发性化合物和感官特征的影响:A GC×GC-TOF-MS,E-nose和机器学习分析
Yijing Pan1, Yi Xiao1, Meiliang Zhu1
1Hubei Provincial Engineering Technology Research Center for Chinese Medicine Processing, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China; Hubei Shizhen Laboratory, Wuhan 430065, China.
Journal of pharmaceutical and biomedical analysis
|July 9, 2025
概括
生的加工改变了Eucommiae皮质 (EC),产生了新的挥发性化合物和独特的感觉形状. 这项研究确定了关键的风味标记物,有助于现代化传统中医药加工.
科学领域:
- 植物化学 植物化学
- 分析化学 分析化学
- 传统中国医药 传统中国医药
背景情况:
- 用生加工的Eucommiae Cortex (G-EC) 是一种缺乏标准化的传统制剂.
- 不明确的化学变化和质量标记阻碍了G-EC的现代化.
研究的目的:
- 调查生加工前后EC的挥发性化合物和感官特征.
- 识别关键的风味化合物和化学转化途径.
- 为G-EC标准化和现代化提供基础.
主要方法:
- 综合二维气体染色学飞行时间质谱 (GC×GC-TOF-MS) 用于挥发性分析.
- 电子鼻子 (E-nose) 技术用于感官分析.
- 多变量统计分析和机器学习 (SHAP) 用于数据解释.
主要成果:
- 在G-EC中确定了2806种挥发性化合物,与EC相比,有173种新化合物和64种消除化合物.
- 描述了65个关键的风味化合物,并指出G-EC中增强的木质,草本,新鲜和薄荷的音色.
- 电子鼻子揭示了明显的挥发性特征,其中基,醇和硫化合物是主要的区分因素.
结论:
- 生加工显著改变了Eucommiae Cortex的挥发性特征和感官特征.
- 这项研究为标准化传统中医药加工提供了关键的化学见解.
- 这些发现支持通过定量质量控制对G-EC的现代化.
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