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Updated: Sep 16, 2025

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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针对突变异酸盐脱酶1 (mIDH1) 的新型水素基抑制剂的发现和结构-活性关系研究

Dong Luo1, Maojie Zhang2, Zizhen Liang1

  • 1School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, PR China.

European journal of medicinal chemistry
|July 9, 2025
PubMed
概括

研究人员通过选超过170万种化合物,确定了针对突变异酸脱酶 (IDHs) 的新型抑制剂. 这些抑制剂有效地降低了癌细胞中的基代谢物2-HG,并显示出具有低毒性的癌症治疗潜力.

关键词:
异酸脱酶 1 异酸脱酶 1结构 - 活动关系研究 结构 - 活动关系研究基于结构的虚拟选.

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