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绵羊和菜蛋糕便在农业土壤中促进抗生素耐药性

Chenyu Huang¹, Tianyu Wang², Weibin Chen¹

¹Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Ministry of Agriculture and Rural Affairs Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang Engineering Research Center for Biological Control of Crop Pathogens and Insect Pests, Institute of Pesticide and Environmental Toxicology, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.

Journal of hazardous materials

|July 9, 2025

概括

在农业中使用肥料增加了抗生素耐药性基因 (ARG) 和土壤中的耐药细菌. 绵羊和绿色肥料促进ARG的移动性,丰富宿主,促进它们在农业环境中的传播.

科学领域:

环境科学环境科学
微生物学微生物学
农业科学农业科学

背景情况:

肥料应用是土壤中抗生素耐药基因 (ARG) 和抗生素耐药细菌 (ARB) 的已知驱动因素.
不同肥料处理的土壤中ARG和移动遗传元素 (MGE) 的共发生模式和宿主多样性尚不清楚.

研究的目的:

研究羊和绿对土壤微生物群,抗生素抵抗体和ARG宿主的影响.
探索ARG和MGE的共同发生模式及其对ARG传播的影响.

主要方法:

使用了超基因组合和捆绑技术.
进行了土壤微生物组,抗生素耐药性基因 (ARG) 和移动遗传元素 (MGE) 的分析.

主要成果:

羊和绿都增加了ARG的丰富性和多样性.
绵羊便显著增强了ARG,使其对多种药物,昆,里芬素和宏-林科萨米德-斜谱素 (MLSB) 产生了耐药性.
MGEs促进了特定ARG的移动性,羊便改变了细菌群体,丰富了具有获得耐药性的机会性病原体.

结论:

菜蛋糕便和羊便增加了ARG-MGE的同时发生,并丰富了潜在的ARG宿主.
肥料应用促进了农业土壤中ARG的传播,造成环境和健康风险.

关键词:

在 ARG 中,主机是 ARG 的主机.抗生素耐药性基因是抗生素耐药性的基因.菜蛋糕便是一种便.绵羊便是羊的便之一.土壤土壤土壤.

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