通过过印刷和过成型,从混合制造的平板电脑中释放结构调节的药物
Han Xu1, Farnoosh Ebrahimi1, Ke Gong1
1PRISM Research Institute, Technological University of the Shannon, Athlone N37 HD68, Ireland.
International journal of pharmaceutics
|July 9, 2025
概括
混合制造将3D打印和注射成型相结合,用于个性化药物. 过度打印提供了设计驱动的药物释放,而过度成型提供了强大的,持续的输送,推进了个性化制药制造.
科学领域:
- 制药制造业 制药制造业 制药制造业
- 材料科学 材料科学 材料科学
- 药物输送系统 药物输送系统
背景情况:
- 混合制造集成了3D打印和注射成型,用于可扩展的个性化口服剂型.
- 过度打印和过度成型是两种不同的混合战略,可能会对药物产品的性能产生影响.
研究的目的:
- 系统地比较混合制造中的超印和超成型.
- 评估它们对药片微观结构,药物释放和加工的影响.
- 确定最佳配方并了解药物释放机制.
主要方法:
- 使用Taguchi L9实验设计进行配方优化.
- 采用热挤出和通过超印和超成型的双层平板制造.
- 使用包括SEM,微CT,DSC和XRD在内的技术来表征片.
主要成果:
- 过度打印的片子显示有多孔结构,使得Fickian扩散控制药物释放速度更快.
- 过度成型的药片表现出紧的结构,导致异常的,扩散放松控制的释放.
- 药物释放在过度打印的片中取决于设计参数,而在过度成型的片中取决于药物加载.
- 在15%的药物负载下确定了最佳的灯丝配方.
结论:
- 过度打印可以实现个性化,设计驱动的药物释放.
- 过度成型提供了强度和受控的,持续的药物输送.
- 这些混合技术为个性化制药制造提供了互补的方法.
相关概念视频
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