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Updated: Sep 16, 2025

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轻度至中度的缺乏与甲状腺功能的关联-系统性审查和元分析
Tonje Eiane Aarsland1, Inger Aakre2, Tonje Holte Stea3
1Women's Clinic at Lillehammer Hospital, Innlandet Hospital Trust, Lillehammer, Norway; Center for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Advances in nutrition (Bethesda, Md.)
|July 9, 2025
概括
在大多数人群中,轻度至中度的缺乏似乎不会影响甲状腺激素水平. 这次审查发现,状态和甲状腺功能在各种年龄组和疾病之间没有明确的关联.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 对于甲状腺激素的产生至关重要,对人类健康至关重要.
- 严重的缺乏会影响甲状腺功能,但轻度到中度缺乏的影响不太清楚.
- 甲状腺激素调节新陈代谢,生长和发育.
研究的目的:
- 系统地审查和总结有关轻度至中度的缺乏和甲状腺激素功能之间的相关性的观察性研究.
- 为了研究这种不同人群之间的关联,包括婴儿,儿童,青少年,成年人和孕妇/哺乳期妇女.
- 澄清状态对甲状腺刺激激素 (TSH),自由甲状腺素 (fT4) 和自由三甲状腺素 (fT3) 的影响.
主要方法:
- 在Medline Ovid,Embase Ovid和Cochrane Central数据库 (2022年11月,2024年2月) 中进行的系统文献搜索.
- 包括观察性研究 (横截面,纵向,队列) 检查轻度至中度的缺乏 (以尿酸度定义) 和甲状腺功能标志物.
- 针对孕妇的特定结果进行的元分析.
主要成果:
- 总共包括了72项研究,涵盖了各种人口群体.
- 所有人口群体的大多数研究都没有发现状态与甲状腺功能之间的明显关联.
- 对8项孕妇研究的元分析显示,与充足的状态相比,TSH,ft4或ft3水平没有显著差异.
结论:
- 综述发现,轻度至中度的缺乏与婴儿,儿童,青少年,成年人或孕妇/哺乳期妇女的甲状腺功能之间没有明确的联系.
- 目前的证据表明,轻度至中度的缺乏可能不会显著改变一般人群中的甲状腺激素水平.
- 可能需要进一步的研究来证实这些发现,并探索潜在的微妙效应或特定的亚群.
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