华山煮剂通过肝肠交叉交流改善了与代谢功能障碍相关的脂肪性肝病
Qin Dong1, Yang Wang1, Yuxin He1
1School of Food and Bioengineering, Food Microbiology Key Laboratory of Sichuan Province, Xihua University, Chengdu, 610039, China.
Journal of ethnopharmacology
|July 9, 2025
概括
华江 (HGJD) 通过改善肝功能和调节肠道微生物群,有效治疗与代谢功能障碍相关的脂肪性肝病 (MASLD). HGJD通过FXR/FGF15/SHP2/CYP7A1通路调节胆汁酸生物合成和脂肪酸代谢,增强肠道屏障.
科学领域:
- 综合医学是一个整体的医学.
- 肝病学 肝病学是一种肝病学.
- 微生物组研究 微生物组研究
背景情况:
- 华中药 (HGJD) 是一种传统的中医药,在临床上用于与代谢功能障碍相关的脂肪性肝病 (MASLD).
- 众所周知,HGJD可以缓解肝脏,缓解抑郁症和具有抗炎作用.
- 在MASLD中HGJD治疗作用的精确机制需要进一步阐明.
研究的目的:
- 综合研究HGJD通过肝肠交叉声调节MASLD的机制.
- 确定关键的分子和微生物途径,参与HGJD的疗效.
主要方法:
- 使用高脂肪饮食建立了一个MASLD大鼠模型.
- 使用各种生理和生化指数评估HGJD疗效.
- 采用非向性肝脏代谢学,16S rRNA测序和短链脂肪酸 (SCFA) 分析.
- 使用的胆汁酸 (BA) 准代谢学,免疫组织化学,西式涂抹,qPCR和ELISA以进行机械验证.
主要成果:
- 在MASLD大鼠中,HGJD显著降低了肝脏脂肪的积累,并改善了肝脏功能.
- HGJD调节的不和脂肪酸和初级胆汁酸生物合成.
- HGJD调节了肠道微生物群组成,增加了肠道SCFA,并重新平衡了肠道和肝脏BA平衡.
- 确定了FXR/FGF15/SHP2/CYP7A1通路对于HGJD的肝肠交叉调节至关重要.
- HGJD抑制了脂质生成,激活了脂质氧化,加强了肠道屏障,并减少了肝炎.
结论:
- HGJD通过编排肝肠交叉声调节来改善MASLD.
- 关键机制包括调节肠道微生物群依赖的BA生物合成和FXR/FGF15/SHP2/CYP7A1通路.
- HGJD还影响脂肪酸代谢,并提供肠道屏障保护,共同促进其治疗效果.
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