相关实验视频

Updated: Sep 16, 2025

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy

Published on: October 13, 2023

迪奥斯科雷亚尼波尼卡马基诺:解开多目标机制和自身免疫性疾病治疗中的临床潜力

Ling Zhou¹, Jinli Luo², Yu Wei³

¹Chengdu University of Chinese Medicine, No.37, Shierqiao Road, Jinniu District, Chengdu, Sichuan, 610075, China; Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No.5, North Line Court, Xicheng District, Beijing, 100053, China.

Journal of ethnopharmacology

|July 9, 2025

概括

迪奥斯科雷亚尼波尼卡马基诺 (DnM) 通过调节炎症和亡途径,对自身免疫性疾病 (ADs) 显示出希望. 它的生物活性化合物提供了多目标方法,在诸如类风湿性关节炎等疾病中证明了有效性和良好的安全性.

科学领域:

植物药理学植物药理学
免疫学免疫学免疫学
传统中国医药传统中国医药

背景情况:

自免疫性疾病 (ADs) 由于其高患病率和对生活质量的严重影响,存在重大挑战.
传统的AD治疗通常会引起不良反应,需要探索替代疗法.
传统中国医学 (TCM),包括神尼波尼卡马基诺 (DnM),为ADs提供了多组分和多目标的治疗潜力.

研究的目的:

研究DnM在治疗ADS中的治疗潜力和多目标机制.
阐明DnM对免疫细胞和关键信号通路的调节作用.
为推进ADS治疗和研究提供全面的植物药理学视角.

主要方法:

在七个数据库中进行系统的文献搜索.
对DnM的化学成分,质量控制,临床观察,药理机制和毒理学的全面审查.
对DnM与ADS常规药物治疗策略的比较分析.

主要成果:

DnM及其成分调节T淋巴细胞增殖和TLR4/NF-κB通路.
DnM抑制促炎性细胞因子 (TNF-α,IL-1β,IL-6) 并通过Fas/FasL和Bcl-2/Bax通路调节细胞亡.
在类风湿性关节炎,自身免疫性甲状腺炎,牛皮和全身性红斑狼中观察到显著的治疗疗效,具有有利的安全性.

结论:

在ADS中,DnM通过调节关键的炎症和亡途径 (NF-κB,STAT3,TGF-β/Smad,Fas/FasL,Bax/Bcl-2) 来产生多目标效应.
临床证据支持DnM在类风湿性关节炎和哈希莫托甲状腺炎中的疗效.
需要进一步进行大规模随机对照试验,以验证DnM在多种AD的治疗潜力.

关键词:

自身免疫性疾病自身免疫性疾病化学成分化学成分化学成分临床疗效临床疗效迪奥斯科雷亚尼波尼卡机器人分子机制的分子机制

更多相关视频

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase G6PI-Induced RA Mice

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase G6PI-Induced RA Mice

Published on: January 31, 2020

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

相关概念视频

Autoimmune Disorders

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...

Inflammatory Bowel Disease IV: Pharmacological Management

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...