与年轻成年人相比,健康老年人对跨直流刺激的反应变异性增加:系统性审查和元分析
Anna Elisabeth Fromm1, Catalina Trujillo-Llano1, Ulrike Grittner2
1Department of Neurology, Universitätsmedizin Greifswald, Greifswald, Germany.
Brain stimulation
|July 9, 2025
概括
与年轻人相比,老年人对跨直流刺激 (tDCS) 的反应变化更大. 这表明需要个性化的tDCS方法来提高老年人群的治疗疗效.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 康复科学 康复科学 康复科学
背景情况:
- 认知和运动功能随着年龄的增长而下降,影响日常生活.
- 跨直流刺激 (tDCS) 与行为训练相结合,可以减轻与年龄相关的衰退.
- 对tDCS的个体反应变异性可能会掩盖疗效并使研究结果复杂化.
研究的目的:
- 系统地审查和元分析与tDCS相关的认知和运动反应中的与年龄相关的变化.
- 量化比较年轻人和健康的老年人之间的tDCS反应变化.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 搜索了PubMed和Cochrane对接受tDCS的年轻人和老年人的比较研究.
- 在19项研究 (390名老年人,384名年轻人) 中使用日志转换变量系数 (lnCVR) 量化行为变化.
主要成果:
- 与年轻人相比,健康的老年人对活跃的tDCS的反应变异性显著更高 (21%更高).
- 在模拟tDCS条件下,在年龄组之间没有观察到显著的变异性差异.
- 在老年人与年轻人之间,活性tDCS的lnCVR为-0.24 (p=0.02).
结论:
- 晚年与对tDCS的反应行为变异性增加有关.
- 这种定量证据强调了对老年人个性化tDCS策略的需要.
- 定制tDCS干预措施对于优化老年人群治疗效果至关重要.
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