NOX4 作为泛癌预后生物标志物和瘤发生中的治疗标
Jiting Sun1,2, Zhiyuan Gong3, Lijie Zheng1,2
1Central Laboratory, Wanbei Coal Electric Group General Hospital, Suzhou, 234011, China.
Scientific reports
|July 9, 2025
概括
NADPH氧化酶4 (NOX4) 通过增加活性氧物种 (ROS) 来驱动癌症的进展. 抑制NOX4在治疗多种癌症方面表现有前途,作为预后生物标志物和治疗点.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物信息学是一种生物信息学.
背景情况:
- NADPH氧化酶4 (NOX4) 调节活性氧物种 (ROS),影响癌症的发展和进展.
- NOX4 影响癌细胞的转变,增殖,迁移,入侵和上皮-介质细胞转换 (EMT).
研究的目的:
- 通过泛癌分析,研究NOX4在多种癌症类型的瘤发生中的作用.
- 为了将NOX4表达与患者预后,免疫透,瘤突变负担 (TMB) 和微卫星不稳定性 (MSI) 相关联.
- 通过体外实验验验证NOX4在乳腺癌细胞增殖和转移中的功能.
主要方法:
- 使用癌症基因组图谱 (TCGA) 数据进行全面的全癌症生物信息学分析.
- 对NOX4表达模式和与临床/分子特征的相关性进行系统分析.
- 在乳腺癌细胞中使用伤口愈合,Transwell和CCK-8试验进行体外验证.
主要成果:
- 在包括乳腺癌在内的各种癌症中,NOX4被显著上调.
- 较高的NOX4表达与较差的患者预后,增加的免疫细胞透,更高的TMB和MSI相关.
- 下调NOX4抑制了乳腺癌细胞的扩散和转移.
结论:
- NOX4在泛癌瘤发生过程中发挥着重要作用.
- NOX4是一种潜在的预后生物标志物和各种癌症的治疗点.
- 向NOX4可能为抗瘤治疗提供一种新的策略.
更多相关视频
07:08Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
Published on: February 2, 2024
920
19:44Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen
Published on: May 30, 2012
18.8K
相关概念视频
02:23Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
02:57Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K
01:41Non-Canonical Wnt Signaling Pathways
7.4K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.4K
02:07Tumor Progression
6.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.5K