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Updated: Sep 16, 2025

Inner Mitochondrial Membrane Sensitivity to Na+ Reveals Partially Segmented Functional CoQ Pools
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Published on: July 20, 2022

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辅酶Q头组中间体可以改善线粒体脑病变

Guangbin Shi1,2, Claire Miller3, Sota Kuno1,2

  • 1Department of Radiation Oncology, NYU Grossman School of Medicine, New York, NY, USA.

Nature
|July 9, 2025
PubMed
概括

在遗传缺陷的小鼠中,补充4- 曼德拉酸 (4- HMA) 或4- 基酸 (4- HB) 恢复了辅酶Q10 (CoQ10) 的合成. 这种方法也改善了患有相关线粒体疾病的患者的神经症状.

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