在患有痴呆症的老年人中,流感疫苗有效性与慢性疾病之间的关联
1Meuhedet Health Services, Tel Aviv, Israel.
Scientific reports
|July 9, 2025
概括
在80岁以上患有严重痴呆症的成年人中,接种流感疫苗并没有减少肺炎或住院治疗. 未接种疫苗的人群风险较低,这表明目前的疫苗策略可能需要为这一群体进行调整.
科学领域:
- 老年学是一门学科.
- 传染性疾病 传染性疾病
- 神经学 神经学
背景情况:
- 建议老年人接种流感疫苗,以预防严重疾病.
- 在患有严重痴呆症的人群中,流感疫苗的疗效尚未得到充分证实.
- 痴呆症可能会改变免疫反应和疾病表现,影响疫苗的有效性.
研究的目的:
- 评估流感疫苗接种对80岁及以上严重痴呆症成年人住院和肺炎发病率的影响.
- 在这个脆弱人群中确定肺炎和住院的风险因素.
主要方法:
- 追溯队列研究的设计.
- 包括2052名80岁以上患有严重痴呆症的个人.
- 使用后勤回归模型进行分析,以评估疫苗接种状态,肺炎发病率和住院率.
主要成果:
- 没有接种疫苗的老年人患有严重痴呆症的肺炎和住院率较低.
- 女性性别和未接种疫苗的身份被确定为保护因素 (OR=0.389,95% CI=0.206-0.733).
- 这项研究表明,在这个特定的人群中,流感疫苗接种的保护作用可能会减少.
结论:
- 与普通老年人相比,在患有严重痴呆症的老年人中,接种流感疫苗可能对肺炎和住院治疗的保护较少.
- 目前的流感疫苗接种策略可能需要为患有严重痴呆症和并存疾病的个人量身定制.
- 需要进一步的研究,以优化流感预防这一高风险群体.
相关概念视频
Vaccinations
45.3K
Overview
45.3K
Pneumonia V: Nursing management and Prevention
2.5K
Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
2.5K
Factors Affecting Illness
4.5K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
4.5K
Alzheimer's Disease: Overview
675
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
675
Dementia
173
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
173
Alzheimer's Disease: Treatment
265
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
265


