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Updated: May 3, 2026

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肝脏特异性的ANGPTL8表达促进阿尔茨海默氏病的进展,通过激活微质灭酶

Jiarui Wei1,2, Lin Hu1, Shufan Xu1

  • 1Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei Provincial Clinical Research Center for Umbilical Cord Blood Hematopoietic Stem Cells, Department of pharmacology of School of Basic Medical Sciences, Department of Geriatrics & General Medicine of Taihe Hospital, Hubei University of Medicine, 30 Renmin South Road, Shiyan, Hubei, 442000, China.

Journal of neuroinflammation
|July 9, 2025
PubMed
概括

肝蛋白ANGPTL8通过激活大脑炎症,加速阿尔茨海默病的发展. 抑制ANGPTL8,与甲胺一样,通过减少神经炎症和改善认知来治疗AD有希望.

关键词:
第八个角度阿尔茨海默病的疾病阿尔茨海默病的疾病.肝 - 大脑轴微质皮质灭症 (microglial pyroptosis) 是一种微质灭症.神经炎症是一种神经炎症.

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