萨尔维亚·斯皮诺萨 (Salvia spinosa) 对引起内牙感染的菌 (Enterococcus faecalis) 的抗菌活性:一个体外,活体外和体内研究
Wedad M Nageeb1, Sherouk Hussein Adam2, Nihal Ali3
1Department of Medical Microbiology and Immunology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. wedad_saleh@med.suez.edu.eg.
BMC complementary medicine and therapies
|July 9, 2025
概括
萨尔维亚螺旋提取物对Enterococcus faecalis表现出强大的抗菌活性,为根管感染提供了一个有希望的天然替代品. 它的有效性,特别是与氧化相结合时,超过了传统的治疗方法.
科学领域:
- 微生物学 微生物学
- 牙周内科医院 牙周内科医院 牙周内科医院
- 自然产品化学 自然产品化学
背景情况:
- Enterococcus faecalis经常在根管中持续存在,导致使用标准氧化药物治疗失败.
- 由于毒性较低和成本效益较高,人们正在寻找天然草药替代品来治疗内药物.
研究的目的:
- 评价Salvia spinosa及其与氧化的组合,作为抗Enterococcus faecalis.alis的内运管内药物.
- 为了比较它们的有效性与标准氧化治疗在原生根管感染模型中的有效性.
主要方法:
- 使用光盘扩散试验和原生根管感染模型来测试Salvia spinosa提取物,氧化及其对Enterococcus faecalis.alis的组合.
- 在化分析中,研究了Salvia spinosa活性化合物与Enterococcus faecalis表面蛋白的相互作用.
主要成果:
- 萨尔维亚螺旋提取物及其与氧化组合的抗菌效果明显高于单独的氧化.
- 像Flavone和Flavonone这样的特定化合物显示出强烈的结合Enterococcus faecalis表面蛋白,识别了潜在的药物标.
结论:
- 萨尔维亚螺旋 (Salvia spinosa) 是一种有前途的天然抗菌剂,用于治疗根管内牙感染.
- 需要进一步的研究来探索其作为替代性内药物的潜力.
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