菌体治疗对控制葡萄球菌生物膜的有效性:系统性审查
Zahra Mobarezi1,2, Amir Hossein Esfandiari1,2, Samaneh Abolbashari2
1Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
European journal of medical research
|July 9, 2025
概括
菌体在对抗抗生素耐药细菌和生物膜方面表现有前途. 需要进一步的研究,以优化菌体疗法作为安全有效的替代品或补充抗生素.
科学领域:
- 微生物学 微生物学
- 生物技术是生物技术.
- 传染性疾病 传染性疾病
背景情况:
- 抗生素耐药细菌,特别是形成生物膜的细菌,对全球健康构成重大挑战.
- 菌体 (菌体) 是感染细菌的病毒,正在成为一种可行的治疗选择.
- 菌体疗法提供了一种有针对性的方法来消除细菌病原体,包括耐药菌株.
研究的目的:
- 系统地审查菌体对抗抗生素和药物耐药性葡萄球菌株形成的生物膜的疗效.
- 评估菌体衍生酶和整个菌体在生物膜降解和细菌清除中的有效性.
- 探索菌体与其他抗微生物药物的潜在协同作用.
主要方法:
- 对2012年至2024年10月期间发表的研究进行全面的系统审查.
- 在主要的科学数据库中进行的搜索:Embase,Web of Science,PubMed和Scopus.
- 纳入标准侧重于菌体对抗耐药性葡萄球菌生物膜的有效性;不相关的研究被排除在外.
主要成果:
- 菌体衍生酶 (内素,脱聚酶) 和整个菌体在降解生物膜和消除细菌方面表现出有效性.
- 菌体与抗生素或其他药物的联合治疗可以增强生物膜去除.
- 潜在的应用涵盖了各种感染类型,包括医疗植入物和不同体液中的感染类型.
结论:
- 菌体是一个有前途的独立或补充治疗黄金葡萄球菌生物膜.
- 进一步的研究对于确定临床使用的最佳菌体选择,剂量和施用策略至关重要.
- 研究菌体-抗生素协同作用,安全性和环境影响对于推进菌体治疗至关重要.
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