黄素 (luteolin) 和原素 (apigenin) in vivo的潜在抗癌作用和毒性
1Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR, USA.
概括
在临床前研究中,素和阿皮基宁显示出抗癌潜力,在动物模型中抑制癌细胞生长. 需要进一步的研究来克服临床成功的挑战.
科学领域:
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
- 在瘤学瘤学.
背景情况:
- 丁醇和阿皮基宁是植物中发现的黄类化合物,以抗炎和抗氧化特性而闻名.
- 这些化合物已在体外和动物模型中证明对各种癌症类型的抗癌活性.
研究的目的:
- 审查体内证据,以检查黄素和阿皮基宁的抗癌作用.
- 总结它们的作用机制和毒性概况.
- 讨论将临床前发现转化为临床应用的挑战.
主要方法:
- 在体内研究的全面文献综述 关于黄素和原素的研究.
- 关于动物肝脏,肺,胃,结肠,乳腺,胰腺,前列腺和皮肤癌的研究分析.
- 检查毒性数据和临床试验限制.
主要成果:
- 在各种动物癌症模型中,素和阿皮基宁表现出显著的抗癌作用.
- 在临床前环境中研究了作用机制和毒性概况.
- 目前没有明确的临床证据支持它们作为抗癌剂的有效性.
结论:
- 临床前数据表明,醇和阿皮基宁是有前途的抗癌药物.
- 将这些发现转化为人类临床试验存在重大挑战.
- 用先进模型和优化交付进行进一步的研究对于临床翻译至关重要.
更多相关视频
13:18Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma
Published on: March 3, 2023
1.4K
09:50Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
9.4K
相关概念视频
Cancer Prevention
6.3K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.3K
Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K
Combination Therapies and Personalized Medicine
5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K
