甲酸在儿科刺激性肠综合征中的疗效:随机的安慰剂控制的基于多组的临床试验
Fernanda Cristofori1, Francesco Maria Calabrese2, Ilaria Iacobellis2
1Interdisciplinary Department of Medicine, Pediatric Section, Children's Hospital' Giovanni XXIII', University of Bari Aldo Moro, Bari, Italy.
丁酸有效地减少了患有刺激性肠综合征 (IBS) 的儿童的症状. 这种治疗还改善了肠道微生物群和代谢概况,显示了儿科IBS管理的前景.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究的研究.
- 营养科学 营养科学
背景情况:
- 刺激性肠综合征 (IBS) 是一种普遍存在的功能性胃肠疾病,没有最佳的治疗方法.
- 目前的IBS管理包括非药理学和药理学方法.
- 了解肠道微生物群的作用对于开发新的IBS疗法至关重要.
研究的目的:
- 评估补充丁酸补充剂在缓解儿童IBS症状方面的疗效.
- 评估丁酸对肠道微生物群组成的影响.
- 用多组学方法分析代谢特征的变化.
主要方法:
- 一个随机的,安慰剂控制的双盲试验,涉及51名被诊断患有IBS的儿童 (4-17岁).
- 干预措施:每天500毫克丁酸或安慰剂8周,然后进行4周的随访.
- 结果指标:视觉模拟量表 (VAS),胃肠道症状评分量表 (GSRS),16S元taxonomics和代谢学.
主要成果:
- 与安慰剂相比,丁酸显著改善了治疗成功率 (73%对3.8%,p<0.0001).
- 在丁酸盐组中观察到VAS和GSRS得分的显著降低.
- 微生物群分析显示,有益细菌增加 (例如,Lachnospiraceae) 和促炎性细菌减少 (例如,Ruminococcus gnavus).
- 代谢学证实了短链脂肪酸 (SCFA) 和挥发性有机化合物 (VOC) 的改变.
结论:
- 补充丁酸是有效的减少儿童患者的IBS症状.
- 治疗促进了肠道微生物群和代谢概况的有利转变.
- 丁酸盐显示出作为儿科IBS治疗剂的潜力,需要进一步的大规模研究.
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