Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

489
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
489
Other Pulmonary Disorders01:17

Other Pulmonary Disorders

913
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
913
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

379
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
379
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

374
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
374
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

594
The pathophysiology of pneumonia involves the following steps:
594
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

342
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
342

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Macrophage-specific therapy blocks the lung's mechanosensitive immune response to alveolar distension.

JCI insight·2025
Same author

Studying the Pulmonary Endothelium in Health and Disease: An Official American Thoracic Society Workshop Report.

American journal of respiratory cell and molecular biology·2024
Same author

Life-saving effect of pulmonary surfactant in premature babies.

The Journal of clinical investigation·2024
Same author

The pathogenesis of influenza in intact alveoli: virion endocytosis and its effects on the lung's air-blood barrier.

Frontiers in immunology·2024
Same author

Rescue of alveolar wall liquid secretion blocks fatal lung injury due to influenza-staphylococcal coinfection.

The Journal of clinical investigation·2023
Same author

Mitochondria of lung venular capillaries mediate lung-liver cross talk in pneumonia.

American journal of physiology. Lung cellular and molecular physiology·2023

相关实验视频

Updated: Sep 16, 2025

Inducing Acute Lung Injury in Mice by Direct Intratracheal Lipopolysaccharide Instillation
11:07

Inducing Acute Lung Injury in Mice by Direct Intratracheal Lipopolysaccharide Instillation

Published on: July 6, 2019

25.5K

瘦素和急性肺部疾病

Alice Huertas1, Jahar Bhattacharya2

  • 1Université Paris-Saclay, School of Medicine, DYNAMIC Lab, Le Kremlin-Bicêtre, France.

Comprehensive Physiology
|July 10, 2025
PubMed
概括

素是一种参与新陈代谢的激素,在肺部健康和急性呼吸困扰综合征 (ARDS) 中起着复杂的作用. 它对肺部免疫和炎症的影响仍在研究中,特别是在肥胖方面.

科学领域:

  • 内分泌学 在内分泌学.
  • 免疫学 免疫学 免疫学
  • 肺部病理学 肺部病理学

背景情况:

  • 瘦素主要来自白色脂肪组织,调节新陈代谢,免疫力和炎症.
  • 莱普还作为肺部的细胞因子类激素,通过OBR受体和JAK-STAT3 / PI3K通路调节免疫反应.
  • 莱普会影响肺部成熟和膜发育.

研究的目的:

  • 探索丁在急性肺部疾病中具有争议的作用,特别是急性呼吸困扰综合征 (ARDS).
  • 调查ARDS中的"肥胖悖论",肥胖可能会给予保护.
  • 为了澄清瘦素对肺炎的影响及其与代谢障碍的相互作用.

主要方法:

  • 审查现有的关于莱普在肺生理学和病理学中的功能的文献.
  • 对研究ARDS"肥胖悖论"的研究进行分析.
  • 检查冲突的动物模型数据关于丁在急性肺损伤 (ALI) 中的作用.

主要成果:

  • 莱普在ARDS中的作用仍在争论中;一些证据表明,与肥胖相关的超莱普血症可能具有保护作用.
  • 潜在的保护机制包括免疫调节,增强中性粒细胞招募和改善巨细胞功能.
  • 肥胖引起的瘦素耐药性可能会抵消潜在的益处,动物研究显示,瘦素对肺部损伤的影响有矛盾的结果.
关键词:
雅克斯坦的路径.肺部急性肺损伤是什么急性呼吸困扰综合征是什么过高莱普丁血症的发生肥胖的悖论 肥胖的悖论

更多相关视频

A Method for Generating Pulmonary Neutrophilia Using Aerosolized Lipopolysaccharide
08:33

A Method for Generating Pulmonary Neutrophilia Using Aerosolized Lipopolysaccharide

Published on: December 15, 2014

11.9K
Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
05:45

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing

Published on: October 25, 2019

6.1K

相关实验视频

Last Updated: Sep 16, 2025

Inducing Acute Lung Injury in Mice by Direct Intratracheal Lipopolysaccharide Instillation
11:07

Inducing Acute Lung Injury in Mice by Direct Intratracheal Lipopolysaccharide Instillation

Published on: July 6, 2019

25.5K
A Method for Generating Pulmonary Neutrophilia Using Aerosolized Lipopolysaccharide
08:33

A Method for Generating Pulmonary Neutrophilia Using Aerosolized Lipopolysaccharide

Published on: December 15, 2014

11.9K
Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
05:45

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing

Published on: October 25, 2019

6.1K

结论:

  • 莱普在肺炎和ARDS中的确切作用需要进一步阐明.
  • 了解瘦素与肥胖等代谢障碍的相互作用,对于开发有针对性的ARDS疗法至关重要.
  • 需要进一步的研究来解决相互矛盾的发现,并确定勒在肺部疾病中的治疗潜力.