口腔癌治疗中的植物化学创新:用天然化合物向瘤性途径
Punniyakoti V Thanikachalam1, Mahalakshmi Devaraji1, Nandhini Jayaprakash2
1Department of Chemistry, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India.
Journal of complementary & integrative medicine
|July 10, 2025
概括
天然植物化学物质通过诱导亡和抑制转移来治疗口腔状细胞癌 (OSCC) 是有前途的. 需要进一步的临床研究来克服生物可用性挑战,并将这些化合物纳入患者护理.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
背景情况:
- 口腔状细胞癌 (OSCC) 是一个重大的全球健康挑战,死亡率高,常规治疗选择有限.
- 对于OSCC的传统疗法经常受到药物耐药性,复发和全身毒性的阻碍,需要新的治疗策略.
研究的目的:
- 审查关于天然植物化学品在口腔状细胞癌 (OSCC) 治疗中的治疗潜力的临床前证据.
- 在临床前的OSCC模型中探索植物化学品的作用机制,疗效和输送系统.
主要方法:
- 对最近的临床前研究 (体外和体内) 的叙述性综述,调查OSCC的植物化学物质.
- 合成有关植物化学物质的数据,如类,黄类,类,类和类.
- 基于纳米技术的输送系统的评估,以提高植物化学疗效.
主要成果:
- 植物化学物质通过诱导亡,氧化应激调节,免疫调节和转移抑制在OSCC模型中表现出抗癌作用.
- 临床前研究表明,各种植物化学物质具有细胞毒性和瘤抑制性.
- 纳米技术提高了植物化学物质的生物可用性和治疗疗效,解决了交付挑战.
结论:
- 天然植物化学物质作为OSCC管理的替代或补充剂具有转化前景.
- 进一步的临床验证对于解决药物动力学限制,潜在的非目标效应和有限的临床试验数据至关重要.
- 将植物化学物质整合到OSCC治疗中需要克服当前的临床前限制并进行强大的临床试验.
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