在维持血液透析的患者中,肌肉间脂肪组织和肌肉功能
R Gulsah Dilaver1, Mert Demirci1, Rachelle Crescenzi2
1Department of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Physiological reports
|July 10, 2025
概括
在晚期慢性病 (CKD) 中,肌肉间脂肪组织 (IMAT) 较高,与炎症和肌肉强度降低有关. 减少IMAT可能会改善CKD患者的治疗结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 肌肉生理学 肌肉生理学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 萨科佩尼亚是晚期慢性病 (CKD) 的常见病症,与患者的不良结果有关.
- 肌肉间脂肪组织 (IMAT) 积累可能通过代谢和炎症机制对肌肉功能产生负面影响.
研究的目的:
- 为了比较接受维持血液透析 (MHD) 和健康对照患者之间的IMAT水平.
- 研究IMAT,炎症,代谢标志物和MHD患者的肌肉功能之间的关联.
主要方法:
- 一项涉及25名MHD患者和23名对照者的横截面研究.
- 牛肉肌磁共振成像 (MRI) 用于量化IMAT.
- 评估了身体组成,炎症标志物 (hs-CRP,TNF-α,IL-6),胰岛素耐药性,循环无细胞线粒体DNA (ccf-mtDNA) 和手握强度.
主要成果:
- 与对照组相比,MHD患者的IMAT显著增加 (p < 0.01).
- 在MHD患者中观察到TNF-α,IL-6和hs-CRP的升高水平 (p <0.01).
- IMAT与MHD患者的IL-6和对照组的TNF-α正相关,与整体队列中的手握强度相反相关 (p < 0.01).
结论:
- 增加的IMAT在MHD患者中很普遍,并且与系统性炎症的增加有关.
- IMAT可能有助于CKD观察到的功能衰退.
- 向IMAT为改善CKD肌肉健康提供了潜在的治疗策略.
相关概念视频
01:25Hemodialysis III: Nursing Management
196
The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this...
196
01:25Hemodialysis I: Introduction
310
Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
310
01:24Hemodialysis II: Procedure and Complications
143
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
143
01:02Hypodermis
5.4K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
5.4K
01:28Chronic Kidney Disease III: Interprofessional Care
82
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
82
01:25Peritoneal Dialysis III: Nursing Management
157
Peritoneal dialysis, or PD, utilizes the peritoneal membrane as a filter to eliminate excess fluid and waste products. Effective nursing management is essential for ensuring patient safety, preventing complications, and promoting optimal function of the peritoneal dialysis process.Assessment and MonitoringNurses must thoroughly assess the patient before, during, and after each dialysis session. Regular monitoring includes vital signs, daily weight, fluid intake and output, and laboratory values...
157