确定肥胖的临界生命阶段对大脑功能网络的贡献
Pei Xiao1, Yan Li2, Jiayuan Dai3
1Center for Non-Communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
CNS neuroscience & therapeutics
|July 10, 2025
概括
终身体重对大脑连接有不同的影响. 由出生体重和儿童体重指数 (BMI) 表示的早期肥胖症因果关系影响大脑网络,强调了及时干预的必要性.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 肥胖与大脑功能的改变有关,但其在不同生命阶段的因果影响尚未得到充分理解.
- 调查整个生命过程中体重和大脑功能连接之间的因果关系对于理解发育影响至关重要.
研究的目的:
- 为了研究不同生命阶段 (出生体重,儿童体重指数 (BMI) 和成年人体重指数) 的体重与大脑功能连接之间的因果关系.
- 探索潜在的生物机制,包括潜在的媒介和遗传途径,将体重与大脑功能联系起来.
主要方法:
- 孟德尔随机化 (MR) 分析被用来推断生命过程中体重测量和191个休息状态功能磁共振成像 (fMRI) 特征之间的因果关系.
- 使用全基因组关联研究 (GWAS) 的数据,并进行了支持性分析,包括链接不平衡得分回归,局部化,调解MR和全转录组关联研究 (TWAS).
主要成果:
- 成年人群的BMI因果关系与额叶神经活动的增加有关.
- 儿童BMI与运动和注意力网络功能连接性降低有因果关系.
- 出生体重与叶中央执行和默认模式网络的功能连接性下降有因果关系.
- 确定了neurexophilin-3作为一个潜在的调解者,对出生体重对功能连接的影响.
结论:
- 体重对大脑功能网络产生了不同的,特定于生命阶段的因果关系.
- 早期的体重,特别是出生体重和儿童的BMI,对大脑连接有很大的影响.
- 需要在整个生命过程中采取有针对性的干预措施,以解决肥胖对大脑健康的持续影响,特别是从早期开始.
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