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体质指数与血造干细胞移植后的存活率之间的关联
Han-Sang Baek1, Jong Hyuk Lee2, Joonyub Lee3
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
The Korean journal of internal medicine
|July 10, 2025
概括
体重不足的患者在血液造血干细胞移植 (HSCT) 后面临更高的死亡率. 虽然肥胖不是危险因素,但糖尿病会增加死亡率,而失脂症可能会降低后HSCT.
科学领域:
- 血液学 血液学 血液学
- 移植医学 移植医学
- 代谢健康 代谢健康
背景情况:
- 体质指数 (BMI) 和血造干细胞移植 (HSCT) 后的结果之间的关系尚不清楚.
- 代谢性疾病对HSCT后死亡率的影响需要进一步研究.
研究的目的:
- 研究移植前的BMI类别与HSCT后的死亡率之间的关联.
- 检查代谢性疾病 (糖尿病,高血压,脂质失调) 对高血压后死亡率的影响.
主要方法:
- 在韩国一家三级医院 (2009-2021) 接受HSCT的3902名患者的回顾性分析.
- 患者根据BMI进行分类:体重不足 (<18.5公斤/米2),正常 (18.5-22.9公斤/米2),超重 (23.0-24.9公斤/米2),肥胖 (≥25.0公斤/米2).
- 考克斯的比例危险模型分析了与BMI和代谢条件相关的死亡风险.
主要成果:
- 与正常的BMI相比,体重不足患者的死亡率明显高 (调整后HR为1.76).
- 超重和肥胖患者的死亡风险没有增加.
- 糖尿病显著增加死亡风险 (HR 3.36),而新诊断的脂质不良症与较低的死亡率有关 (HR 0.27). 高血压没有显著的影响.
结论:
- 肥胖不是HSCT后生存的预后因素.
- 代谢性疾病对HSCT后的死亡率产生不同的影响,糖尿病带来了显著的风险,脂质失调可能具有保护作用.
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