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Updated: Sep 16, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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通过调节Wnt/PCP通路,RAN有助于在多发性骨髓瘤中产生博特佐米布耐药性

Linmeng Li1, Lu Xu2

  • 1Department of Clinical Laboratory, Zhuji People's Hospital of Zhejiang Province, Zhejiang, China.

Neoplasma
|July 10, 2025
PubMed
概括

拉斯相关核蛋白 (RAN) 在多发性骨髓瘤 (MM) 中被上调,通过激活Wnt/PCP通路,促进癌症生长和对博特佐米布 (BTZ) 的抵抗. 向RAN可能为MM患者提供新的治疗策略.

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