老年人骨质疏松症与心血管风险相关的生物化学标记:回顾性分析
Preeti Nigotia1, Uditkumar Agrawal2, Ashish Sharma3
1Department of Medicine, SRVS Medical College, Shivpuri, Madhya Pradesh, India.
Journal of orthopaedic case reports
|July 10, 2025
概括
骨质疏松症与不健康的胆固醇和同氨酸水平有关,影响骨矿物质密度 (BMD) 并增加心血管疾病 (CVD) 风险. 较低的BMD显著提高了这种风险,表明BMD是潜在的心血管疾病生物标志物.
科学领域:
- 代谢性骨疾病 代谢性骨疾病
- 心血管疾病的研究研究.
- 生物化学标记分析分析
背景情况:
- 骨质疏松症是一种常见的代谢性骨疾病,特别是在老年人中,通常与心血管疾病共同发生.
- 现有的研究表明,骨质疏松症与心血管疾病 (CVD) 之间存在潜在联系.
研究的目的:
- 调查骨质疏松症,关键生化标志物,骨矿物密度 (BMD) 和心血管疾病 (CVD) 之间的关联.
- 评估 BMD 对心血管疾病风险的预测潜力.
主要方法:
- 对280名骨质疏松症患者和182名对照组的截面分析.
- 评估了血清中的甘油三,总胆固醇 (TC),LDL,HDL和同型半氨酸 (HCY) 的水平.
- 评估了生化指数和骨质疏松之间的相关性;比较了心血管疾病的患病率,并使用ROC分析来预测骨质疏松的预测值.
主要成果:
- 发现骨质疏松症和较高的甘油三,TC和LDL水平之间的积极关联.
- 观察到骨质疏松症与高水平的HDL和HCY水平之间存在不良关联.
- 在骨质疏松症患者中降低BMD和更高的心血管疾病发病率;减少BMD显著增加了心血管风险.
结论:
- 骨质疏松症,脂质样本,HCY水平,骨质量和心血管疾病之间存在显著的关联.
- 脱脂症和改变的HCY代谢可能会导致骨质流失和心血管病理.
- 骨髓硬化显示出作为生物标志物的潜力,用于识别心血管风险增加的个体.
更多相关视频
06:04Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
Published on: September 27, 2024
1.1K
08:02Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals
Published on: November 15, 2024
727
相关概念视频
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
222
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
222
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
349
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
349
01:29Bone Disorders
4.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.0K
01:31Osteoclasts in Bone Remodeling
3.2K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.2K
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
298
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
298
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
127
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
127