血清IP-10的增加与核子中PEG-IFNα响应相关,在患有慢性乙型肝炎的患者中接受了核子侧类似物治疗
Wen-Xin Wang1,2, Xiaoyan Li2, Xue-Yuan Jin2
1Peking University 302 Clinical Medical School, Beijing 100039, China.
ILIVER..
|July 10, 2025
概括
血清IP-10水平的早期增加预测了慢性乙型肝炎 (CHB) 患者的治疗反应,这些患者接受了与基化干扰素α (PEG-IFNα) 结合的核类相应物 (NA). 这一发现有助于监测治疗疗效.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 慢性乙型肝炎 (CHB) 的治疗包括核胺类同类物 (NAs) 和基化干扰素α (PEG-IFNα).
- 评估治疗反应,特别是HBsAg损失,仍然是一个临床挑战.
- 干扰素马诱导蛋白10 (IP-10) 是病毒性肝炎的一个潜在生物标志物.
研究的目的:
- 在CHB患者中研究血清IP-10和HBsAg水平之间的关联.
- 评估IP-10作为NA疗法后NA加PEG-IFNα组合治疗后治疗反应的预测标记.
主要方法:
- 在NA治疗后,纳入了99名CHB患者,这些患者的HBsAg较低,HBVDNA无法检测到.
- 患者接受了NA单一治疗或与PEG-IFNα的联合治疗.
- 血清HBsAg,HBV DNA和IP-10水平在12周和24周被监测.
主要成果:
- 在48周后,在NA单疗组中没有观察到HBsAg损失.
- 在组合治疗组中,15名患者实现了HBsAg损失.
- 12或24周血清IP-10水平的适度增加与HBsAg损失和下降显著相关,并预测了治疗反应.
结论:
- 血清IP-10水平的早期,适度增加是接受NA加PEG-IFNα治疗的CHB患者治疗反应的重要预测因素.
- IP-10监测可以帮助个性化和优化CHB治疗策略.
- 这项研究强调了IP-10作为预测CHB患者HBsAg损失的生物标志物的实用性.
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