相关实验视频

Updated: Sep 16, 2025

Radiation Treatment of Organotypic Cultures from Submandibular and Parotid Salivary Glands Models Key In Vivo Characteristics

Radiation Treatment of Organotypic Cultures from Submandibular and Parotid Salivary Glands Models Key In Vivo Characteristics

Published on: May 17, 2019

辐射暴露对口腔粘膜细胞的影响:一个体外研究

Silpi Chatterjee¹, Pallavi Choudhary², Asim Mustafa Khan³

¹Department of Public Health Dentistry, Dr. D.Y.Patil Dental College & Hospital, Dr D.Y.Patil Vidyapeeth, Pune, Maharashtra, India.

|July 10, 2025

概括

辐射暴露会在口腔粘膜细胞中引起显著的DNA损伤和细胞死亡,在剂量较高时损伤会增加. 保护措施对于面临辐射的口腔组织至关重要.

科学领域:

口腔粘膜细胞生物学
辐射毒理学辐射毒理学

背景情况:

辐射暴露可以诱导口腔粘膜细胞中有毒反应和DNA损伤.
这些效应的严重程度取决于在实验室环境中施加的辐射剂量.

研究的目的:

研究不同辐射剂量对口腔粘膜细胞存活率和DNA完整性的影响.
评估辐射暴露对口腔组织的结构和功能后果.

主要方法:

涉及口腔粘膜细胞受控辐射暴露的实验室试验.
细胞存活率的评估.
彗星测定用于评估DNA损伤程度.
显微镜检查细胞结构的变化.

主要成果:

细胞存活率从对照组的98.6%显著下降到8 Gy辐射剂量的40.8%.
随着辐射剂量的增加,细胞结构的改变和DNA损伤的表现变得明显.
彗星测定证实了细胞内DNA损伤的剂量依赖性增加.

结论:

辐射暴露显著损害了口腔组织的防御能力.
实施保护措施至关重要,以防止辐射引起的口腔粘膜损伤.

关键词:

造成的DNA损伤是DNA损伤.暴露于辐射的辐射暴露.细胞活力的细胞活力.细胞毒性细胞毒性遗传毒性遗传毒性遗传毒性在体外 (in vitro) 研究的研究.口腔粘膜细胞是口腔的粘膜细胞.辐射引起的损伤.

更多相关视频

A Co-culture Method to Investigate the Crosstalk Between X-ray Irradiated Caco-2 Cells and PBMC

A Co-culture Method to Investigate the Crosstalk Between X-ray Irradiated Caco-2 Cells and PBMC

Published on: January 30, 2018

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Published on: August 19, 2025

相关概念视频

Mutations

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...