在不同生殖周期的雌驴便微生物群的组成和预测功能
Jingya Xing1, Mingquan Jia1, Guoliang Zhang1
1College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, China.
Frontiers in microbiology
|July 10, 2025
概括
雌驴肠道微生物群的组成在生殖周期之间有显著差异,在怀孕和哺乳期间观察到不同的细菌类和功能. 这会影响营养吸收和宿主健康.
科学领域:
- 兽医科学 兽医科学 兽医科学
- 微生物学 微生物学
- 动物科学动物科学
背景情况:
- 肠道微生物群对于单胃食草动物的营养吸收和健康至关重要.
- 关于雌驴在整个生殖周期中的肠道微生物组成和功能的信息有限.
研究的目的:
- 描述不同生殖阶段雌驴的肠道微生物组成和功能特征.
- 确定与怀孕,哺乳期和非怀孕状态相关的肠道微生物群的差异.
主要方法:
- 来自雌驴的便样本的高通量测序.
- 阿尔法多样性分析以评估微生物多样性.
- 主坐标分析 (PCoA) 用于比较微生物社区结构.
- 使用KEGG正义学家 (KO) 进行微生物通路的功能预测.
主要成果:
- 在生殖周期之间没有观察到α多样性的显著差异.
- 细菌系的相对丰富性有显著差异:乳房期间的Firmicutes更高,怀孕期间的Bacteroidetes更高.
- 在PCoA中,孕和哺乳期/非孕之间,肠道微生物群的组成有所不同.
- 怀孕与Bacteroidetes和Alloprevotella的占主导地位有关,而哺乳期显示Firmicutes和未识别的Clostridiales的患病率更高.
- 在整个生殖周期中,在与免疫系统,新陈代谢和细胞运动有关的功能途径中发现了显著的差异.
- 与孕相比,哺乳的新陈代谢和免疫功能可能会降低.
结论:
- 雌驴肠道微生物群的组成和功能在生殖周期之间有很大差异.
- 这些变化与宿主健康和营养代谢有关.
- 研究结果为优化马匹在不同生殖阶段的营养和管理提供了洞察力.
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