抓握强度和与年龄相关的眼睛疾病:从观察性,门德尔随机化和调解分析的见解
Chao Chen1,2,3,4, Dongling Guo1,2,3,4, Jiaqi Meng1,2,3,4
1Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Ophthalmology science
|July 10, 2025
概括
较低的握力与较高的白内障,绿内障和糖尿病视网膜病变 (DR) 风险有关. 代谢变化,特别是脂质和omega-3脂肪酸,调解这些关联,突出显示眼睛疾病的潜在治疗点.
科学领域:
- 眼科医生 眼科 眼科
- 代谢学 代谢学 代谢学
- 遗传学 遗传学 是一个
背景情况:
- 握力是整体身体健康和肌肉功能的关键指标.
- 与年龄相关的眼睛疾病,包括白内障,玻璃眼,糖尿病视网膜病变 (DR) 和与年龄相关的黄斑变性 (AMD),构成重大公共卫生挑战.
- 握力和这些特定的眼睛疾病之间的关系,以及潜在的代谢机制,仍然不完全理解.
研究的目的:
- 调查握力和与年龄相关的主要眼部疾病 (白内障,绿内障,DR,AMD) 之间的截面和因果关系.
- 探索新陈代谢变化的调解作用在握力和眼睛健康之间的关系.
- 确定这些关联中涉及的特定代谢模式和生物标志物.
主要方法:
- 利用了307,796名英国生物库参与者的数据.
- 使用后勤回归用于横截面关联和两个样本的门德尔随机化用于因果关系评估.
- 使用核磁共振和主要成分分析分析了血代谢概况 (n=152,376),以确定代谢模式.
- 进行调解分析以评估代谢生物标志物和模式的作用.
主要成果:
- 较低的握力与较高的白内障,绿内障和DR的患病率有关.
- 基因预测较高的握力显示,白内障,DR和AMD的风险降低.
- 代谢模式,特别是改变的脂质和降低的欧米茄-3多不和脂肪酸 (PUFA),显著调解了握力和白内障/DR之间的联系.
结论:
- 握力降低是发展白内障,青光眼和DR的重要危险因素.
- 代谢变化,特别是脂质代谢和omega-3PUFA水平的破坏,是这种关系中的关键调解者.
- 这些发现表明,保持肌肉强度和解决代谢失调可能是预防与年龄相关的眼睛疾病的重要因素.
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