重症COVID-19患者的神经表现的发生率:一个低资源设置体验
Sasa Dragic1, Andrea Dolencuk2, Danica Momcicevic1
1Medical Intensive Care Unit, University Clinical Centre of the Republic of Srpska and Medical Faculty University of Banja Luka, Banja Luka, BIH.
Cureus
|July 10, 2025
概括
神经学问题,如意识受损,对重症COVID-19患者的结果产生重大影响,特别是在资源较低的环境中. 对这些肺外表现的早期监测对于患者的管理和生存至关重要.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 可能会影响神经系统由于血管酶转化酶2 (ACE2) 受体的存在.
- 重症COVID-19患者的神经表现可能会影响临床结果,特别是在资源有限的环境中.
研究的目的:
- 评估在低资源环境中的重症COVID-19患者的神经症状的发生率和重要性.
- 确定这些神经系统疾病对患者结果的影响.
主要方法:
- 从2020年10月到2021年2月,对262名危急COVID-19患者进行了回顾性观察性研究.
- 数据收集包括人口统计,临床和神经学表现细节.
- 使用描述性统计和费舍尔精确测试进行统计分析.
主要成果:
- 58.5%的患者至少出现了一种神经问题.
- 最常见的是:意识受损 (19.5%),头痛 (10.2%),肌痛 (8%).
- 意识障碍与致命结局相关 (p=0.01),而急性多基根性尿路炎则表明有利的结局 (p=0.04).
结论:
- 神经症状在重症COVID-19患者中很常见,并显著影响结果.
- 观察到神经学表现 (例如,年龄,性别) 的人口差异.
- 对肺外症状,包括神经症状的全面监测对于管理重症COVID-19患者至关重要.
相关概念视频
Pneumonia III: Complications and Assessment
452
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
452
Acute Respiratory Failure-IV
236
Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...
236
Aneurysm II: Clinical Manifestations and Diagnostic Studies
26
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
26
Disorders of the Nervous Tissue
1.6K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.6K
Factors Affecting Illness
4.5K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
4.5K
Acute Kidney Injury III: Clinical Manifestations
97
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
97


