用于检测肝细胞癌的挥发性有机化合物-A范围审查
Sayed Metwaly1,2,3, Alicja Psica4, Opeyemi Sogaolu4
1Division of Internal Medicine, Aberdeen Royal Infirmary, NHS Grampian, Scotland, Aberdeen, AB25 2ZD, United Kingdom.
ILIVER..
|July 10, 2025
概括
早期发现肝细胞癌 (HCC) 是至关重要的. 本综述探讨了呼出的挥发性有机化合物 (VOC) 作为潜在的HCC非侵入性查工具,但需要标准化和大型研究.
科学领域:
- 在瘤学瘤学.
- 生物化学 生物化学
- 肺部病理学 肺部病理学
背景情况:
- 肝细胞癌 (HCC) 是癌症死亡的主要原因,存活率低.
- 晚期诊断限制了HCC的治愈治疗选择,需要早期查方法.
研究的目的:
- 批判性地评估和综合当前关于使用排气挥发性有机化合物 (VOCs) 进行非侵入性HCC检测的知识.
- 确定基于VOC的HCC查研究的进展和挑战.
主要方法:
- 对2023年3月24日之前发表的研究进行了系统的电子搜索.
- 包括9个出版物 (2个在体外,7个临床) 遵循PRISMA指南.
- 在临床研究中分析了420名HCC患者和630名对照者的数据.
主要成果:
- 研究表明,VOC组合在HCC诊断中可能发挥作用.
- 呼出的气息中没有单一的挥发性生物标志物被最终归因于HCC.
- 当前研究中存在显著缺乏共识和标准化.
结论:
- 呼出的VOC显示出作为一种非侵入性方法来检测HCC的前景.
- 为了验证研究结果,需要对大型多中心人群进行进一步的研究.
- 方法的标准化和可靠生物标记物的识别对于临床应用至关重要.
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