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用上皮层介质细胞过渡标记的瘤芽 - 乳腺癌的新奇预后工具

Priyadharshini Kumar¹, Meghashree Vishwanath¹, Saranyabai Selvaraj¹

¹Department of Pathology, ACS Medical College and Hospital, Dr. M.G.R. Educational and Research Institute, Chennai, Tamil Nadu, India.

Journal of mid-life health

|July 10, 2025

概括

瘤芽 (TBs) 和上皮-介质细胞过渡 (EMT) 标志物是乳腺癌转移的关键指标. 高结核病得分与预后不佳相关,有助于早期识别和积极治疗.

科学领域:

在瘤学瘤学.
病理学病理学病理学

背景情况:

乳腺癌是一个重大的全球健康问题,转移是死亡的主要原因.
表皮-介质细胞过渡 (EMT) 是癌症进展的关键过程,使瘤细胞能够入侵周围组织.
瘤芽 (TBs) 是微观的癌细胞集群,表明具有侵入性潜力,并与转移有关.

研究的目的:

开发一种量化乳腺癌瘤芽 (TBs) 的方法.
调查结核病得分,EMT标志物表达和侵袭性乳腺癌的临床参数之间的关系.

主要方法:

对47例侵袭性乳腺癌病例进行了回顾性分析.
瘤芽 (TBs) 在H&E染色部分中进行了评估,并使用免疫组织化学 (IHC) 检测EMT标记物.
使用统计分析,包括奇平方测试,以确定结核病,EMT标志物和临床数据之间的关联.

主要成果:

在47例中,30例的结核病得分较低 (≤4/10 HPF),17例的结核病得分较高 (>4/10 HPF).
高结核病得分与SNAIL,TWIST和N-cadherin的强烈表达,以及E-cadherin的低表达有关.
低结核病得分与高E-cadherin表达和低SNAIL,TWIST和N-cadherin表达相关.

结论:

在瘤芽 (TB) 存在和表皮-介质细胞过渡 (EMT) 标志物的表达之间存在显著的正相关性.
高结核病得分与淋巴血管入侵,淋巴结转移和晚期瘤等级有显著联系.
将结核病评分和EMT标志物评估整合到乳腺癌管理中可以支持更个性化的患者方法.

关键词:

乳腺癌是什么乳腺癌这是E-cadherin.这是一种N-cadherin.一个的子一个扭曲的世界.表皮介质介质的过渡.

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