创伤后应激障碍 (PTSD) 严重程度的变化如何介导创伤后应激障碍和SUD同时发生的治疗期间和治疗后的物质使用障碍 (SUD) 严重程度:来自Harmony项目结果
Denise A Hien1, Jordan A Gette2, Shannon M Blakey3
1Center of Alcohol and Substance Use Studies, Rutgers University-New Brunswick, Piscataway, NJ, USA.
Addiction (Abingdon, England)
|July 10, 2025
概括
在治疗期间,创伤后应激障碍 (PTSD) 严重程度的降低介于物质使用障碍 (SUD) 的改善. 对于药物使用,PTSD症状的减少也预测了治疗后SUD的进一步改善.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 成 药物 药物 药物 药物
背景情况:
- 创伤后应激障碍 (PTSD) 经常与物质使用障碍 (SUD) 一起发生,导致严重程度增加和治疗结果较差.
- 了解治疗并发性PTSD和SUD的间接途径对于优化干预至关重要.
研究的目的:
- 调查PTSD严重程度的变化如何影响不同治疗方式SUD严重程度的变化.
- 为了检查这些关系,在治疗并发性PTSD和SUD期间和之后.
主要方法:
- 利用了来自Project Harmony的数据,这是一项虚拟临床试验,涉及36个PTSD+SUD随机对照试验的4046名参与者.
- 采用多级介导线性增长建模来分析治疗有效性和结果调解.
- 对比了八种活跃治疗与通常治疗 (TAU) 对于酒精和毒品使用的结果.
主要成果:
- 创伤后应激障碍严重程度的降低与创伤重点心理治疗与AUD药物结合的酒精使用严重程度的改善,以及创伤重点综合心理治疗,AUD药物和PTSD药物.
- 同样,PTSD严重程度的降低促进了创伤为重点的心理治疗+AUD药物,创伤为重点的综合心理治疗,AUD药物,PTSD药物和安慰剂药物的药物使用严重程度的改善.
结论:
- 对于患有并发性PTSD和SUD的人来说,PTSD症状严重程度的降低是治疗期间减少酒精和药物使用的关键调解因素.
- 此外,对于那些有药物使用障碍的人来说,PTSD症状的减少似乎在治疗完成后推动了SUD的后续改善.
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