在慢性中风中通过心血管运动调节大脑刺激性:一项随机对照试验
Lynden Rodrigues1,2, Kevin Moncion3, Bernat De Las Heras1,2
1School of Physical and Occupational Therapy, McGill University, Montréal QC, Canada.
Neurorehabilitation and neural repair
|July 10, 2025
概括
慢性心血管运动 (CE) 在中风幸存者中改善皮质脊髓刺激能力 (CSE),重新平衡大脑半球. 运动强度没有显著改变这些神经可塑性效应,这表明CE的好处不管是HIIT还是MICT. 需要进一步研究功能相关性.
科学领域:
- 神经科学是一个神经科学.
- 康复医学 康复医学 康复医学
- 运动生理学 运动生理学
背景情况:
- 通过跨磁刺激 (TMS) 测量的皮层脊髓刺激 (CSE) 是神经可塑性的关键指标.
- 之前的研究表明,一次性高强度间歇训练 (HIIT) 和中等强度持续训练 (MICT) 暂时改善了中风幸存者的CSE.
- 重复炼的长期影响和炼强度对中风中CSE的影响尚不清楚.
研究的目的:
- 研究12周HIIT与MICT心血管运动 (CE) 计划对慢性中风幸存者的CSE的影响.
- 为了使用TMS比较CSE测量的变化,无论是ipsilesional (ILH) 和contralesional (CLH) 半球.
- 为了分析运动强度对神经可塑性标记物的影响,在中风后恢复.
主要方法:
- 一个随机对照试验 (NCT03614585) 涉及56名慢性中风幸存者 (>6个月后的中风).
- 参与者被随机分配到12周的HIIT (n=28) 或MICT (n=28) CE计划中.
- 包括静止运动唤起潜力 (MEP) 幅度,静止运动值 (rMT) 和皮质内促进 (ICF) 在内的CSE测量在基线和干预后使用TMS进行了评估.
主要成果:
- 总体而言,CE显著增加了ILH休息MEP振幅,并重新平衡了半球间rMT和ICF比率.
- 探索性分析显示,在两组组合中,rMT和ICF的显著减少,ILH的静止MEP幅度增加.
- 在HIIT和MICT组之间没有观察到CSE变化的显著差异,这表明运动强度没有缓解效应.
结论:
- 慢性心血管运动,无论强度如何 (HIIT与MICT),都能增强脑半球的激发性CSE,并减少中风幸存者的半球间不平衡.
- 运动强度似乎不是调节这些运动诱导的神经质变化的关键因素.
- 需要进一步的研究,以阐明这些观察到的CSE变化的功能意义在中风后恢复的背景下.
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