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Updated: Sep 16, 2025

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
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一个tRNA基因有可能激活干扰素信号传递,涉及选择性终止,并可被La蛋白/SSB抑制

Alan C Kessler1, Sandy Mattijssen1, Gennady H Margolin2

  • 1Section on Molecular and Cell Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, United States.

Nucleic acids research
|July 10, 2025
PubMed
概括

人类tRNA基因TRT-TGT4-1通过RNA聚合酶III (Pol III) 转录激活干扰素刺激基因 (ISG) 反应. 特定的终端序列和侧面元素控制这种非正规的免疫信号通路.

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