高度血清性癌症的特征 涉及卵巢表面上皮质-腹膜结合点的高度血清性癌症
Jeffrey D Seidman1, Jayashree Krishnan2
1Pathology Consultant, Gaithersburg, Maryland.
概括
卵巢表面上皮质 - 腹膜结合点是高度血清癌 (HGSC) 发展的关键地点. 了解其正常组织学是识别女性早期癌变的关键.
科学领域:
- 妇科病理学 妇科病理学
- 在瘤学瘤学.
- 皮质生物学 皮质生物学
背景情况:
- 表皮结是已知的致癌热点.
- 卵巢表面上皮质 - 腹膜结合处的卵巢部在人类的组织学特征很差.
- 这个结位代表了介质体的介质体和卵巢表面表皮之间的过渡区域.
研究的目的:
- 通过组织学来描述正常的卵巢表面上皮质-腹膜结.
- 评估这个结节区域对子宫外高度血清癌 (HGSC) 的参与.
主要方法:
- 从76个正常的卵巢中检查了143个结节区域的组织学检查.
- 从150名患有子宫外HGSC的患者150个结节区域的组织学检查.
- 评价上皮质形态,划界,以及甲状腺增生或恶性瘤的存在.
主要成果:
- 正常的结点通常是很好的划分,立方形或柱状卵巢表面上皮质 (OSE) 过渡到平面半体 (79%).
- 在11%的正常病例中观察到过渡性细胞代谢.
- 在HGSC病例中,41%的瘤距离结点2毫米以内,表面和树皮参与程度各不相同.
- 在7例病例中,在结节区域发现了内皮质HGSC,在5个可评估的输卵管中,在2个输卵管中同时发现了STIC.
结论:
- 卵巢表面上皮质-腹结处表现出正常卵巢中独特的组织学特征.
- 这个结节区域经常被HGSC所涉及,突出显示了它在卵巢癌发病过程中的重要性.
- 早期检测HGSC可能需要仔细检查这个特定的解剖部位和相关的上皮质内含.
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