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Updated: Sep 16, 2025

A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
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探索β-乳酸与DacB1的相互作用:揭开对抗耐药性Mycobacterium结核病的最佳疗法

Mary Nantongo1,2, David C Nguyen3, Eunjeong Shin2,4

  • 1Department of Molecular Biology and Microbiology, Case Western Reserve University (CWRU), Cleveland, Ohio, USA.

mBio
|July 10, 2025
PubMed
概括

结核病 (TB) 治疗可以通过重新使用β-乳糖抗生素来改善. 像伊米佩内姆这样的卡巴类药物有效地抑制了Mtb DacB1酶,显示出对抗耐药性Mycobacterium结核病的组合疗法的希望.

关键词:
D,D-碳氧酸酶,D-碳氧酸酶.耐药结核病是抗药性结核病的一种.结核病菌菌菌的结核病菌的结核病菌.酸甘油可以是酸甘油.这是β-lactam抗生素的抗生素.这是β-乳酸酶抑制剂.

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