短暂的呼吸暂停和周期性呼吸对早产婴儿的长期发育后果
Rosemary S C Horne1, Alicia K Yee1, Leon S Siriwardhana1
1Department of Paediatrics, Monash University, Melbourne, Australia.
Pediatric pulmonology
|July 10, 2025
概括
过早出生的婴儿花了更多时间与短暂的呼吸暂停,特别是定期呼吸,在2岁时表现出较差的运动发育. 这些发现表明,即使是短暂的呼吸暂停,对于早产婴儿来说也并非无害.
科学领域:
- 新生儿生理学 新生儿生理学
- 发育儿科 发育儿科
背景情况:
- 过早出生的婴儿经常经历短暂的呼吸暂停,这可以是孤立的,也可以是定期呼吸的模式.
- 在早产婴儿的呼吸暂停时间的长期发育影响需要进一步的研究.
研究的目的:
- 评估短暂呼吸暂停的持续时间与早产婴儿2岁发育结果之间的关联.
主要方法:
- 23名早产婴儿 (28-32周妊娠年龄) 在睡眠期间在多个时间点进行监测,从月经后32周年龄到6个月的校正年龄.
- 计算了呼吸暂停的总睡眠时间的百分比. 婴儿根据中位积累性呼吸暂停时间被分组.
- 在2岁时进行了发育评估 (贝利尺度,行为问卷),并使用ANCOVA进行了组对组比较.
主要成果:
- 呼吸暂停时间高于中位数的婴儿在运动,社会情绪和适应性行为领域的未调整得分趋向于较低.
- 经过对混因素进行调整后,在中位数以上的呼吸暂停组中,运动综合评分和感知灵敏度明显较低 (p < 0.05).
结论:
- 在临床稳定的早产儿中,短暂的呼吸暂停时间的增加,特别是定期呼吸,与2岁时运动结果的减少有关.
- 这些发现表明,早产婴儿的短暂呼吸暂停和周期性呼吸不是良性的,需要注意.
更多相关视频
05:45Delivery of In Vivo Acute Intermittent Hypoxia in Neonatal Rodents to Prime Subventricular Zone-derived Neural Progenitor Cell Cultures
Published on: November 2, 2015
7.4K
07:36Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
11.5K
相关概念视频
Sleep Apnea
225
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
225
Respiratory Volumes and Capacities I
1.2K
Assessing the respiratory rate and rhythm for a complete minute is crucial for evaluating the breathing pattern. Even a minor increase in the patient's average respiratory rate, by as little as three to five breaths per minute, is an early and vital indicator of respiratory distress. Patients with a respiratory rate exceeding twenty-four breaths per minute require close monitoring to determine the physiological alterations. This careful observation is essential for prompt recognition and...
1.2K
Breathing
60.4K
The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
60.4K
Alterations in Respiration II
1.0K
There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
1.0K
Pulmonary Cycle: Exhalation
1.8K
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
1.8K
Acute Respiratory Failure-II
374
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
374
