一个令人震惊的摄入:故意消耗塑料爆炸物导致发作
Seth Jones1, Irene Li2, Jasmine Gale2
1Department of Emergency Medicine, Division of Medical Toxicology, University of Massachusetts Medical School, University Campus, 55 Lake Avenue North, Worcester, MA, 01655, USA. Seth.Jones@lahey.org.
概括
摄入含有旋风 (RDX) 的C4爆炸物,可能导致发作和精神状态的改变. 用二类药物和 levetiracetam 及时治疗导致两名军人完全康复.
科学领域:
- 毒理学 毒理学 毒理学
- 神经学 神经学
- 军事医学 军事医学
背景情况:
- C4是一种广泛使用的军用塑料爆炸物,主要由旋石 (皇家拆除爆炸物或RDX) 组成.
- C4毒性是神经障碍的一个未被认可的原因,包括改变精神状态和发作.
研究的目的:
- 报告了两起摄入C4的军事人员的案例.
- 突出C4摄入的临床表现和管理.
主要方法:
- 两名军事人员在摄入C4后出现了发作和震的案例报告.
- 用静脉注射的二类药物进行急性治疗,随后服用 levetiracetam 48 小时.
- 重症监护室的观察和出院没有神经系统的后果.
主要成果:
- 在C4摄入后,这两名患者都经历了目击性发作,震和小皮疹.
- 一名患者在最初的摄入数小时内出现了第二次发作.
- 用二类药物和 levetiracetam 成功管理导致神经系统完全恢复.
结论:
- 在C4中的环旋酸作为GABAA抗剂,导致摄入后的神经症状.
- 摄入C4是一种罕见但重要的发作和精神状态改变的原因.
- 管理需要支持性护理,呼吸道保护和GABAergic药物.
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